产品货号：
Z15200
中文名称：
CYP2E1抗体
英文名称：
Anti-CYP2E1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CYP2E1 Antibody |
| 指标别名 | 4 nitrophenol 2 hydroxylase;CPE1;CYP2E;CYP2E1;CYP-2E1;CYP2E1-Specific;CYPIIE1;Cytochrome P450 2E1;Cytochrome P450 J;P450 J;P450C2E |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CYP2E1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of mouse CYP2E1(94-112aa KNEFSGRGDIPVFQEYKNK),identical to the related rat sequence. |
| 实际分子量 | 57KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CYP2E1,also known as P450IIE1,is a member of the P450IIE subfamily which is ethanol-inducible.It has at least 1 gene which is mapped to 10q24.3-qter,and a second is likely in rat and in man.Both the rat and human proteins encoded by this gene contain 493 amino acids and calculated molecular masses of 56,634 and 56,916 daltons,respectively.In addition,genetic polymorphisms in the 5-prime flanking region of the human P450IIE1 gene affected its binding of transacting factor and changed its transcriptional regulation,which may lead to interindividual differences of microsomal drug oxidation activity.P450IIE1 is an important enzyme for the catalysis of the conversion of ethanol to acetaldehyde and to acetate in humans,and it is also involved in the metabolism of nitrosamines.Due to the possible correlation of P450IIE1 genes with malignancy,clinical studies of RFLP patterns of these genes in cancer may be useful. |
| Uniprot ID | Q05421 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cytochrome P450,family 2,subfamily E,polypeptide 1 |
| 蛋白名全称 | Cytochrome P450 2E1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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